Free PDF Her-2: The Making of Herceptin, a Revolutionary Treatment for Breast Cancer

Free PDF Her-2: The Making of Herceptin, a Revolutionary Treatment for Breast Cancer

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Her-2: The Making of Herceptin, a Revolutionary Treatment for Breast Cancer

Free PDF Her-2: The Making of Herceptin, a Revolutionary Treatment for Breast Cancer

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From the Inside Flap

Two years after she underwent a mastectomy and chemotherapy, Barbara Bradfield's aggressive breast cancer had recurred and spread to her lungs. The outlook was grim. Then she took part in Genentech's clinical trials for a new drug. Five years later she remains cancer-free. Her-2 is the biography of Herceptin, the drug that provoked dramatic responses in Barbara Bradfield and other women in the trials and that offers promise for hundreds of thousands of breast cancer patients. Unlike chemotherapy or radiation, Herceptin has no disabling side effects. It works by inactivating Her-2/neu--a protein that makes cancer cells grow especially quickly-- produced by a gene found in 25 to 30 percent of all breast tumors. Herceptin caused some patients' cancers to disappear completely; in others, it slowed the progression of the disease and gave the women months or years they wouldn't otherwise have had. Herceptin is the first treatment targeted at a gene defect that gives rise to cancer. It marks the beginning of a new era of treatment for all kinds of cancers. Robert Bazell presents a riveting account of how Herceptin was born. Her-2 is a story of dramatic discoveries and strong personalities, showing the combination of scientific investigation, money, politics, ego, corporate decisions, patient activism, and luck involved in moving this groundbreaking drug from the lab to a patient's bedside. Bazell's deft portraits introduce us to the remarkable people instrumental in Herceptin's history, including Dr. Dennis Slamon, the driven UCLA oncologist who played the primary role in developing the treatment; Lily Tartikoff, wife of television executive Brandon Tartikoff, who tapped intoHollywood money and glamour to help fund Slamon's research; and Marti Nelson, who inspired the activists who lobbied for a "compassionate use" program that would allow women outside the clinical trials to have access to the limited supplies of Herceptin prior to FDA approval of the drug. And throughout there are the stories of the heroic women with advanced breast cancer who volunteered for the trials, risking what time they had left on an unproven treatment. Meticulously researched, written with clarity and compassion, Her-2 is masterly reporting on cutting-edge science. "From the Hardcover edition.

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About the Author

Robert Bazell is the chief science correspondent for NBC News. His reports, which appear on the NBC Nightly News, Today, and Dateline NBC, have won every major award in broadcasting. He has written for many publications, including The New Republic, The New York Times, and The New York Times Magazine. He lives in New York with his wife, Margot, and daughter, Stephanie.

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Product details

Paperback: 240 pages

Publisher: Random House; 1 edition (August 25, 1998)

Language: English

ISBN-10: 0812991842

ISBN-13: 978-0812991840

Product Dimensions:

6 x 0.5 x 8.9 inches

Shipping Weight: 8 ounces (View shipping rates and policies)

Average Customer Review:

4.6 out of 5 stars

50 customer reviews

Amazon Best Sellers Rank:

#644,898 in Books (See Top 100 in Books)

Reading this book, and yes I saw the movie...again pointed out, How Very BLESSED I am to be alive! If Dr Slamon had given up on his fight to bring Herceptin to fruition...I and a very large number of women would have been dead years ago! I was able to really experience all the problems and difficulties he and many others faced. Reading about those who fought hard for its inception increases my respect and admiration. If not for those who worked so diligently to bring these developments to life many would be dead. In 1999 I was diagnosed with this aggressive form of Cancer. I truly appreciate all those women who went before me. After 8 years on Herceptin, with an OK from Dr Slamon, My weekly Herceptin was discontinued. I have been Blessed now with 16 years of life, when I had originally been given a few months.

A compelling read about the discovery of the drug Herceptin. My education crossed paths with both Dr. Dennis Salmon and Dr. John Glaspy during my internship at UCLA in 1992. Both of them were my attending physicians during my internship. In fact, my first rotation out of medical school (from UCSF) was on the solid oncology unit at UCLA and a few short months later it was on the bone marrow transplant unit. I encountered many deathly sick patients and sadly many died. I wish I knew what Dr. Slamon and Dr. Glaspy were doing at the very time of my internship to help save the lives of their patients. They are to be commended for advancing the treatments for breast cancer. All these years later I wish that my internship had started with one of the oncology attendings telling me this: "Your internship is going to suck. You will take care of devastatingly sick patients many of whom will die. You will be fatigued and get little sleep. You will become attached to them and feel the pain that they and their families go through. And often, it will be hopeless, but we want you to know that as you are on the wards taking care of them we are working on the advances that one day will help to save their lives. If I had only known about those first patients ever to receive HERCEPTIN it might have changed not only my year of internship but all the years since. I recognize that it is in the 26 years since doing my internship that many new treatments have in fact come along to save or at least add years to people's lives. It was 9 years after my internship that the drug GLEEVEC was approved--I wish it had been available to save the life of one of my patients, JK. I watched as the attendings and fellows and residents and myself were completely helpless in saving him. Robert Bazell is to be commended for not only reporting the science, but the politics and bureaucracy of bringing a life saving drug to market.

Very interesting to read since I am now using this miracle drug for a recent diagnosis. I was surprised to see it was published so long ago (1998) and I'd love it to be updated. The personal stories of the women who fought for this drug, and those who didn't get to benefit from it, are the most compelling. I am so grateful to benefit from all the pioneering work that's been done. So why does this still cost $10,000.00 for each infusion 16 years later? I'm getting it for a year, maybe $180,000.00, nearly all covered by insurance. An update on the costs of developing, marketing, and distributing the drug would be helpful.

Terrific book about discovery of Her-2 and Herceptin. Although published in 1998, it gives the back story of these discoveries and the journey to FDA approval. Very informative and inspirational. As a breast cancer patient, I am grateful for everyone who participated in the development of the drug and the women who participated in the trials that resulted in widespread availability for women who are Her-2 positive.

I am a breast cancer patient currently winding down on my treatment of Herceptin....4 more to go!!! I had 4 rounds of AC then 12 rounds of Taxol and Herceptin with 3 rounds of a cousin to Herceptin which I think was prujeta??. Then a bilateral with no des ease evident and no lymph nodes affected. Then 9 months of Herceptin only....this is the treatment for HER2 nue positive in 2013/2014.

It's a very clear, and sometimes passionate, history about how to develop an biopharmaceutical, specially a very difficult one, as a monoclonal antibody.Also and not least, several pesonals histories on women suffering breast cancer

It had really motivating stories of emotional experiences, I read it mostly for the science, and this book contains a lot of new terms that really help enhance information for a future oncologist.

It told me all about the treatment and the hopes of it helping other women like me, looking for for a cure. I have had both the old way of chemo and am now on this Herceptin. A great difference. So far I am showing improvement. I hope it continues. It is such a gentle way of treatment as compared to the old way, where you feel like you are going to die. The old way, burn, slice and poison is such a cruel way to treat a patient, I truly hope this new method continues to help women with the old problem, breast cancer.

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Her-2: The Making of Herceptin, a Revolutionary Treatment for Breast Cancer PDF